Although hawthorn reportedly potentiates the activity of digoxin (Mashour et
al. 1998; Miller 1998), case reports of clinically significant interactions have
not been cited in the
In rat mesenteric artery, hawthorn fruit alcoholic extract counteracted the
effects of phenylephrine, a vasoconstrictive agent (Chen et al. 1993). The
extract completely inhibited the contraction induced by phenylephrine at a
concentration of 1 micromole. The clinical relevance of these experimental
findings is unknown at this time.
Chen ZY, Zhang ZS, Kwan KY, et al: Endothelium-dependent relaxation induced
by hawthorn extract in rat mesenteric artery. Life Sci.
Mashour NH, Lin GI, Frishman WH. Herbal medicine for the treatment of
cardiovascular disease. Arch Intern Med. 1998;158:2225-2234.
Miller LG. Herbal medicinals: selected clinical considerations focusing on
known or potential drug-herb interactions. Arch Intern Med.
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