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| U.S. Brand Names |
| Comhist®; Comhist® LA |
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| Generic Available |
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No |
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| Pharmacological Index |
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Antihistamine/Decongestant Combination |
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| Use |
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Symptomatic relief of rhinitis and nasal congestion due to colds or allergy |
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| Pregnancy Risk Factor |
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C |
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| Usual Dosage |
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Oral: 1 capsule every 8-12 hours or 1-2 tablets 3 times/day |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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Use with caution since phenylephrine is a sympathomimetic amine which could interact with epinephrine to cause a pressor response |
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| Dental Health: Effects on Dental Treatment |
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Chlorpheniramine: Prolonged use will cause significant xerostomia Phenylephrine: Up to 10% of patients could experience tachycardia, palpitations, and dry mouth; use vasoconstrictor with caution |
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| Dosage Forms |
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Capsule, sustained release (Comhist® LA): Chlorpheniramine maleate 4 mg, phenylephrine hydrochloride 20 mg, and phenyltoloxamine citrate 50 mg Tablet (Comhist®): Chlorpheniramine maleate 2 mg, phenylephrine hydrochloride 10 mg, and phenyltoloxamine citrate 25 mg |
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